Open AccessAge-related macular degeneration and Alzheimer disease
Author(s) -
Eren Çerman,
Muhsin Eraslan,
Osman Çekıç
Publication year - 2015
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1406-146
Subject(s) - medicine , macular degeneration , disease , pathogenesis , pathological , degeneration (medical) , alzheimer's disease , apolipoprotein e , vitronectin , pathology , ophthalmology , receptor , integrin
This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
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