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Results: When compared to controls, genotypes associated with low enzyme activity were observed at signifi cantly lower frequencies in both sexes. Of note, high enzyme activity genotypes were more common in patients with MS when compared with medium and low enzyme activity genotypes. *A allele frequency was not diff erent between patients and controls even considering sex; however, there was a good correlation of the presence of the allele with body composition, serum cortisol levels and suppressibility of cortisol, particularly in women with MS. Conclusion: Our fi ndings suggest that low enzyme activity genotypes seem to be associated with a protective eff ect for the development of MS. Additionally, *A allele carriage aff ects body composition in women but not in men, and the presence of this allele might modulate serum cortisol levels as well as its suppressibility in both sexes, in an inverse manner.

Association of ACP1 genotypes and clinical parameters in patients with metabolic syndrome*