Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4 H -1,2,4-triazole analogues

We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues ( 5a-j ). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 μ " role="presentation"> μ μ \mu M) on nine different panels of 59 cancer cell lines. 2- { " role="presentation"> { { \{ 5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl } " role="presentation"> } } \} phenol ( 5e ) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.