Open AccessA convenient route for the synthesis of new thiadiazoles
Author(s) -
Abdelwahed R. Sayed,
Yasser H. Zaki,
Emad H. Aish
Publication year - 2016
Publication title -
turkish journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 1303-6130
pISSN - 1300-0527
DOI - 10.3906/kim-1505-13
Subject(s) - chemistry , thiadiazoles , methanethiol , intramolecular force , nucleophilic substitution , halide , proton nmr , nucleophile , medicinal chemistry , combinatorial chemistry , organic chemistry , sulfur , catalysis
The present work describes the preparation of new thiadiazoles through a simple intramolecular reaction of mono- and bis-hydrazonoyl halides with methyl hydrogen phenyl carbonimidodithioate or methyl-2-arylidene hy- drazinecarbodithioate. The synthetic method involves nucleophilic substitution followed by intramolecular cyclization reactions mediated by evolution of methanethiol. The structures of the title compounds were elucidated by elemental analyses, and FTIR, MS and NMR spectra.
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