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Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained nal compounds ( 6a{j) were conrmed by spectral data (IR, 1 H NMR, 13 C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a{j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 g/mL.

Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains