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Although insulin resistance and decreased insulin secretion are characteristics of established type 2 DM, which of these metabolic abnormalities is the primary determinant of type 2 DM is controversial. It is also not well known how insulin resistance and beta cell dysfunction influence serum insulin, proinsulin, proinsulin/insulin ratio in type 2 DM.

Serum Insulin , Proinsulin and Proinsulin / Insulin Ratio in Type 2 Diabetic Patients : As an Index of β - Cell Function or Insulin Resistance