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Objective.  We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis.    Methods.  In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints.    Results.  Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p &lt; 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0.    Conclusion.  HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.

the journal of rheumatology/journal of rheumatology

The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography