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To the Editor: We read with great interest Dr. Neogi’s recent editorial on asymptomatic hyperuricemia1, as well as the correspondence from Drs. Marasini and Massarotti2.There are strong associations among hyperuricemia, cardiovascular disease, and the metabolic syndrome3,4. Still, the role of uric acid (UA) in the latter 2 conditions is lacking. Marasini and Massarotti state that “abdominal obesity has been found to be significantly related to serum uric acid levels probably because obesity interferes with urate synthesis and … Address correspondence to Prof. R.O. Day, Level 2, Xavier Building, St. Vincent’s Hospital, Darlinghurst NSW 2010, Australia. E-mail: R.Day{at}unsw.edu.au

Hyperuricemia, Cardiovascular Disease, and the Metabolic Syndrome: Figure 1.