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This study evaluated the physicochemical properties of toothpaste from combined    Caulerpa   racemosa    and    Thunnus    fish bone (Toothpaste    Caulerpa    and    Thunnus    or TCT) and its antibacterial activity towards the colonization of selected cariogenic and periodontal bacterias. Four forms of toothpaste which contained    C.   racemosa    extract and calcium carbonate or bone isolates of tuna and control (F1 (1.5:45); F2 (3:45); F3 (4.5:45); F4 (0:45)) were compared and analyzed for antioxidant activity ( DPPH  assay), organoleptic (sensory), homogeneity, viscosity, pH, and foamability. Antibacterial activity tests were conducted on    Streptococcus   mutans   ,    Staphylococcus   aureus   , and    Porphyromonas   gingivalis   . The antioxidant activity of the group’s (F1, F2, F3, F4) p=0.0001 differed considerably (CI 95%). F3 was the most antioxidant-active formula, with 27.46 ± 3.09%. F3 also had good sensory tests, adequate homogeneity, optimal pH 7.64 ± 0.68, an increased viscosity level of 443.07 ± 0.12, and the least foam formations of 19.28 ± 0.07, all of which are significantly different (p&lt;0.05) from other variations of TCT formulas. Interestingly, F3 has greater inhibition against the activity of selected bacterias. In conclusion, formula 3 (F3) is a recommended toothpaste, made from combined    C.   racemosa    and    Thunnus    fish bone, and has promising physicochemical and antibacterial properties. A further clinical study is urgently needed.

pharmacia

Physicochemical characterization of novel toothpaste from    Caulerpa   racemosa    and    Thunnus    fish bone: Antibacterial potency against colonization of selected cariogenic-periodontal bacteria