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This study aimed to assess the role of D 2  receptor A-241G (rs1799978) genetic polymorphism and olanzapine response and safety in Iraqi schizophrenic patients. The case-control study composed of 100 schizophrenic patients consisting of both genders were recruited from the Psychiatry Outpatient Department and 50 apparently healthy volunteers, served as a control group. Patient response to olanzapine was evaluated with the aiding of the  PANSS  and genotyping of D 2  receptor A-241G (rs1799978) polymorphisms was detected using the nested  PCR  method. The heterozygous (AG) and mutant (GG) alleles of D 2  receptor A-241G (rs1799978) were significantly predominated in schizophrenic patients and absent in healthy volunteers. Schizophrenic patients with the G allele of D 2  receptor A-241G (rs1799978) and who were administered olanzapine exhibited a notable resistance to olanzapine. In conclusion, the genetic polymorphism of D 2  receptor A-241G (rs1799978) was significantly associated with resistance to olanzapine in Iraqi schizophrenic patients.

﻿Association study between D 2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients

Association study between D 2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients