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Background : Fetuin-A is a multifunctional liver-derived glycoprotein that is associated with insulin resistance and might play a role in the pathogenesis of prediabetes and type 2 diabetes ( T2DM ).Objective : This study evaluated the relationship of Fetuin-A with metabolic and vascular parameters in patients with prediabetes and  T2DM .Materials and methods : total 120 obese patients were included. They were divided into three groups: group 1 – without carbohydrate disturbances, group 2 – with prediabetes and group 3 – with type 2 diabetes mellitus.Results : Higher Fetuin-A serum levels were observed in patients with prediabetes and  T2DM  compared to those with normoglycemia. Fetuin-A ≥821 mcg/ml increased the risk for  T2DM  32-fold. Additionally, we found positive correlations between Fetuin-A, vibration perception threshold and toe-brachial index and a negative correlation with neuropathy disability score.Conclusion : Fetuin-A could be predictive for incidents of prediabetes and  T2DM .

Relationship of serum Fetuin-A with metabolic and vascular parameters in patients with prediabetes and type 2 diabetes mellitus