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The polymorphic variants of  CYP1A1  and the deletion of  GSTM1  are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type  GSTM1  (+) and 47% with null  GSTM1 . The frequency in Iquiteño emigrants was 0.72  CYP1A1*2A  and 25%  GSTM1  (-); from Lima 0.67  CYP1A1*2A  and 33% of  GSTM1  (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p &gt; .05.The presence of the risk allele of the  CYP1A1*2A  polymorphism and the deletion in the  GSTM1  gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population