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In Vietnam,    Physalis   angulata   L.  is a wild species growing throughout the country that is often used in traditional medicine. The aim of study was to quantify seven major compounds, including phenolic acids (chlorogenic acid, caffeic acid, p-coumaric acid) and flavonoids (rutin, quercitrin, quercetin, and kaempferol) in three aerial parts of    P.   angulata   . Chromatographic separation was carried out on a Kromasil C 18  column (150 mm × 4.6 mm i.d., 5 µm) with a gradient elution of 0.1% formic acid in acetonitrile, 0.2% ammonium acetate/0.1% formic acid in water and methanol at a flow rate of 1.0 mL/min; detection was at 250 and 300 nm. The limits of detection and quantification were in the ranges of 0.1–0.3 and 0.3–1.0 µg/mL, respectively. The validated method was successfully applied to analyze active compounds in    P.   angulata    and may be a useful tool for quality control of this plant.

Determination of phenolic acids and flavonoids in leaves, calyces, and fruits of Physalis angulata L. in Viet Nam