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Background : Breast cancer chemotherapy with standard drugs such as doxorubicin will induce cardiotoxicity. Therefore, this study aims to evaluate the anticancer activity of    C.   odorata    leaves extract in DMBA induced breast cancer on rats.Methods : Seven groups of    Rattus   novergicus    were used: Four treatment groups of    C.   odorata    extract (500, 1000, 2000, and 4000 mg/kg  BW ), normal control, breast cancer control, and doxorubicin treatment group. The number, volume, and weight of the nodule and the rats’ body weight were compared among groups. Data was analyzed using paired t-test or one-way  ANOVA  with post hoc analysis as appropriate.Results : Significant decline of the number, volume, and weight of cancer nodules was observed in the treatment group ( p  &lt; 0.001). The weight of the cancer nodule at week 16 th  was also significantly reduced in G Co2000  compared to G doxo  ( p  &lt; 0.0001). A significant increase in body weight was also dose-dependent, especially at week 11 th  ( p  &lt; 0.05 in all comparisons) and week 16 th  ( p  &lt; 0.001 in all comparisons).Conclusion : This study suggested that the ethanol extract of    C.   odorata    leaves has anticancer and antiproliferative activity.

pharmacia

The anticancer activity of ethanol extract of    Chromolaena   odorata    leaves in 7,12-Dimethylbenz[a]anthracene in (DMBA) induced breast cancer Wistar rats (   Rattus   novergicus   )