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Five isoflavonoids, i.e. 5-hydroxy-7-methoxy-2’, 5’-dihydroxyisoflavone ( AV4 ), 5, 7-dihydroxy-4’-methoxyisoflavone ( AV6 ), 7-methoxy-5-hydroxy-4’-methoxy-2’-hydroxyisoflavone ( AV7 ), 8-pregnyl genistein ( AV9 ), 5,7-dihydroxy-8-pregnyl-4’-methoxy-2’-hydroxyisoflavone ( AV10 ) and one coumarochromone – sophorophenolone (AV8) were isolated from  EtOAc  of  in vitro  callus cultures of   Astragalus   vesicarius   ssp.   carniolicus  , after enzymatic hydrolysis with  β -glucosidase. Their structures were tentatively elucidated by spectroscopic mean ( 1 H NMR and HR-ESI-MS spectra). Antiproliferative activity of  EtOAc  extract and isolated aglycones against chemosensitive human promyelocyte cell line HL-60 and its multidrug-resistant variant HL-60/Dox was assessed  in vitro . Despite the strong activity of  EtOAc  (IC 50  8.8 µg/mL (HL-6, 72 h) to 11.8 µg/mL (HL-60/Dox, 72 h)), prenylated compound  AV9  showed also antiproliferative activity – 36.1 µg/mL (HL-60 and HL-60/Dox, 72 h).

Antiproliferative activity of extract from in vitro callus cultures of Astragalus vesicarius ssp. carniolicus (A. Kern.) Chater