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: Parvoviruses are DNA viruses of small size. There have been a number of reports indicating the possible effects of B19 infections during pregnancy. These effects include spontaneous abortions, stillbirth, fetal damage, and quite often, fetal anemia with hydrops fetalis.Aim : The aim of this study was the correlation of Epstein-Barr virus ( EBV ) and parvovirus-B19 infections with inflammation levels in placental tissue coming from spontaneous abortions and elective terminations cases. We also investigated whether viral presence could cause spontaneous abortions by associating the expression levels of inflammatory markers with adverse pregnancy outcomes.Materials and methods : One hundred ninety-four placental samples were used, 152 included in the study group coming from spontaneous abortions while 42 controls were used from cases of elective terminations. Hematoxylin and eosin ( H&amp;E ) staining was performed to investigate morphological changes in the tissues, and then indirect immunohistochemistry to evaluate the expression of TNF-α, IL-6, IL-1α, B19, and  EBV . Statistical analysis was performed using SPSS v. 19.0 (IBM).Results : Higher inflammation levels were observed with statistical significance in the spontaneous abortions group ( p &lt;0.001) and they were correlated with statistical significance with B19 or  EBV  presence ( p &lt;0.001). Viral presence was only found in the spontaneous abortions group. Both simple and multiple logistic regression confirmed that viral presence was an independent prognostic factor for high expression of all inflammatory biomarkers with statistical significance ( p &lt;0.001).Conclusions : Our results clearly indicate a specific pattern. Viral presence can deregulate inflammatory processes in the maternal-fetal environment and thus work as a trigger for spontaneous abortions.

Viral-induced inflammation can lead to adverse pregnancy outcomes