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: Exercise-induced desaturation is common in patients with moderate to severe chronic obstructive pulmonary disease ( COPD ). It provides additional information about physical capacity and disease evolution, and it is an important predictor of mortality.Aim : To compare the six-minute walk test ( 6MWT ) and the cardio-pulmonary exercise test ( CPET ) as methods for detection of desaturation in  COPD  patients. To explore the relationship between exercise-related desaturation, symptom questionnaires (mMRC, CAT, and SGRQ), pulmonary function testing ( PFT ), and blood-gas analysis.Patients and methods : Forty adult male  COPD  patients, mean age 67.2±8.4 years (mean ± SD) underwent  6MWT ,  CPET ,  PFT , blood-gas analysis, and scored their symptoms (mMRC, CAT, and SGRQ). Oxygen desaturation was monitored during exercise. Desaturation was defined as a decrease in SpO 2  of ≥4% and values ≤88% held for ≥3 minutes.Results : The studied patients had  COPD  stage 2A – 4D (GOLD 2011). The patients were categorized into two groups – with desaturation (A, n=19) and without desaturation (B, n=21).  CPET  elicited 21 individuals who experienced desaturation, 19 of them desaturated during  6MWT  as well. In the whole group, the percentage of desaturation during  CPET  was 6.6±4.9% compared to 6.0±4.9% during  6MWT  ( p &lt;0.001). There was a significant difference in the maximal oxygen consumption reached by the patients in group A – 16.2±4.5 and group B – 19.9±4.7 ( p =0.016). Desaturation during  6MWT  correlated significantly with that during  CPET  ( r =0.75,  p &lt;0.001).Conclusions : Exercise-related desaturation in patients with moderate to severe  COPD  could easily and reliably be detected by  6MWT .

The six-minute walk test – a reliable test for detection of exercise-related desaturation in patients with chronic obstructive pulmonary disease