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Several epidemiological studies have evaluated the role of illicit drug use in suicide behaviour.Aim:  To assess patients with opioid use disorder and suicidal intent related to behavior, severity of acute poisoning and the most commonly used non-opioid substances.Materials and methods:  This cross sectional study included 67 patients diagnosed with opioid use disorder. The study was conducted at the University Clinic of Toxicology in Skopje over a 5-year period (2013-2017). The following variables were examined: gender, age, duration and route of opioid administration, duration of hospitalization, and types of substances used in acute poisoning. Assessment of patients&amp;rsquo; behavior and severity of poisoning was made by using the Suicide Behaviours Questionnaire-Revised and the Poison severity score.Results:  The majority of patients were male (88.1%). The mean age of patients was 30&amp;plusmn;6.1 years. The average duration of opioid use disorder was 8.5&amp;plusmn;3.9. A single poisoning was found in 62.7%, double poisoning in 25.4%, and triple poisoning in 11.9% of participants. Benzodiazepines were most commonly used by the patients (55.2%). The largest number of patients (32.8%) had minor Poison severity score (PSS), and only 17.9% had severe PSS. None of the patients had a fatal suicide attempt. 86.6% of patients had a score of &amp;ge;7 indicating a high risk of repeat suicide attempts.Conclusion:  Benzodiazepines were most commonly used as a single or combined substance in patients with opioid use disorder. PSS indicated that most of the participants were with minor PSS and with high risk of a repeat suicide attempt.

Non-Opioid Substances Acute Poisonings with Suicidal Intent in Patients with Opioid Use Disorder