English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We studied the level of spontaneous telomere dysfunction in   Rattus   norvegicus   (Berkenhout, 1769) (  Rodentia  ,   Muridae  ) embryonic fibroblasts ( rEFs ) and in cultured in vitro rat pluripotent stem cells ( rPSCs ), embryonic stem cells ( rESCs ) and induced pluripotent stem cells ( riPSCs ), on early passages and after prolonged cultivation. Among studied cell lines,  rESCs  showed the lowest level of telomere dysfunction, while the  riPSCs  demonstrated an elevated level on early passages of cultivation. In cultivation, the frequency of dysfunctional telomeres has increased in all studied cell lines; this is particularly true for dysfunctional telomeres occurring in G1 stage in  riPSCs . The obtained data are mainly discussed in the connection with the specific structure of the telomere regions and their influence on the differential DNA damage response in them.

Dysfunction telomeres in embryonic fibroblasts and cultured in vitro pluripotent stem cells of Rattus norvegicus ( Rodentia , Muridae )