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microRNAs are regarded as promising drugs for glioma gene therapy. However,conventional administration routes, such as oral administration and intravenousinfusion, present low efficiency due to the blood-brain barrier and intercellularretention, thereby limiting their application. Recent studies showed poly(amidoamine) (PAMAM) was a candidate carrier due to its high solubilization, delayedrelease and low toxicity. In the present study, U251 human brain glioma cellswere transfected with the miR-7 gene using PAMAM as the vector to determine thetransfection efficiency and therapeutic effects in vivo and in vitro. We foundthat PAMAM exhibited higher transfection efficiency and longer duration of actioncompared with liposome delivery, and miR-7 efficiently silenced some genes involvedin the epidermal growth factor receptor (EGFR) pathway and achieved favorableeffects in treating glioma in vivo and in vitro. These investigations providea basis for developing high-efficiency micromolecular drug delivery.

Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells