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Gene therapy using human sodium iodide symporter (hNIS) and radioiodinehas been considered promising in a variety of gene therapy trials. However, theoptimal timing of radioiodine application following hNIS gene transfer remainsunknown. The present study aimed to investigate the serial expression of hNISfollowing adenovirus-mediated hNIS gene transfer into anaplastic thyroid carcinoma(ARO) to determine the optimal timing of radioiodine application. Recombinantadenovirus encoding the hNIS gene (rAd-hNIS) was generated using a homologousrecombination reaction. The iodine uptake of rAd-hNIS‑transfected ARO cells graduallyincreased until 120 min post‑125I application but the fold increase, reflectingthe relative uptake of rAd-hNIS‑transfected compared to non‑transfected ARO cells,reached plateau at 60 min post‑125I application. For the in vivo analysis, rAd-hNISwas injected intratumorally into ARO cell xenografts in the thighs of nude mice(n=12). Two, 3, 4 and 6 days after rAd-hNIS injection, γ‑scintigraphic imageswere obtained 60 min following injection of 5.5 MBq of 131I intraperitoneally.Treated/non-treated (T/NT) xenograft count ratios were the highest at day 2 post‑rAd-hNISinjection (2.85±0.61), and gradually decreased thereafter (2.54±0.65, 2.31±0.42and 2.18±0.90 at days 3, 4 and 6 post‑rAd-hNIS injection, respectively). Real‑timepolymerase chain reaction (RT-PCR) and immunohistochemical staining demonstratedthat hNIS expression was the highest at day 2 following rAd-hNIS injection. Inconclusion, the optimal timing for radioiodine administration is day 2 after adenovirus-mediatedhNIS gene transfer into anaplastic thyroid carcinoma.

oncology reports

Determination of the optimal time for radioiodine therapy in anaplastic thyroid carcinoma using the adenovirus-mediated transfer of sodium iodide symporter gene