English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

We have recently demonstrated that a natural dietary supplement BreastDefend(BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganodermalucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalusmembranaceus, Curcuma longa), and purified biologically active nutritional compounds(diindolylmethane and quercetin), inhibits proliferation and metastatic behaviorof MDA-MB-231 invasive human breast cancer cells in vitro. In the present study,we evaluated whether BD suppresses growth and breast-to lung cancer metastasisin an orthotopic model of human breast cancer cells implanted in mice. Oral applicationof BD (100 mg/kg of body weight for 4 weeks) by intragastric gavage did not affectbody weight or activity of liver enzymes and did not show any sign of toxicityin liver, spleen, kidney, lung and heart tissues in mice. Moreover, BD significantlydecreased the change in tumor volume over time compared to the control group (p=0.002).BD treatment also markedly decreased the incidence of breast-to-lung cancer metastasisfrom 67% (control) to 20% (BD) (p&lt;0.05) and the number of metastases from 2.8(0.0, 48.0) in the control group to 0.0 (0.0, 14.2) in the BD treatment group(p&lt;0.05). Finally, anti-metastatic activity of BD in vivo was further confirmedby the downregulation of expression of PLAU (urokinase plasminogen activator,uPA) and CXCR4 (C-X-C chemokine receptor-4) genes in breast tumors. In conclusion,BD may be considered as a biological therapeutic agent against invasive breastcancers.

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer