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The glycoglycerolipid monogalactosyl diacylglycerol (MGDG) isolated fromspinach selectively inhibits the activities of replicative DNA polymerase speciesand suppresses the growth of human cancer cell lines, while not affecting normalhuman cells. Liposomes, carrying surface-bound sialyl Lewis X (SLX) and containingMGDG (SLX-Lipo-MGDG) and the fluorescent dye Cy5.5, were administered intravenouslyto mice bearing HT-29 human colon adenocarcinoma tumors and liposome distributionobserved using fluorescence imaging equipment in vivo. In an in vivo antitumorassay on nude mice bearing HT-29 solid tumors, SLX-Lipo-MGDG was shown to be astronger and more promising suppressor of solid tumors than MGDG alone. Theseresults suggest that spinach MGDG could be developed into an anticancer compound,SLX-Lipo-MGDG could serve as an effective clinical anticancer drug and that theseliposomes may be useful tools as the basis for active targeting drug deliverysystems.

oncology reports

In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach