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Hepatocellular carcinoma (HCC) is one of the most common malignancies. Themain cause of death in HCC patients is tumor progression with invasion and metastasis.However, the underlying mechanisms of HCC invasion and metastasis are still notfully understood. Some studies show that the Notch signaling pathway may participatein tumor invasion and metastasis. However, the mechanisms by which the Notch signalingpathway mediates tumor cell invasion, especially in hepatocellular carcinoma,are not yet known. In the current study, we investigated the anti-invasion effectof the downregulation of the Notch signaling pathway by DAPT in HCC cells. TheNotch signaling pathway inhibitor could suppress invasion of HCC cells via theextracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathways, resultingin the downregulation of matrix metalloproteinase-2 and -9 (MMP-2 and -9) andvascular endothelial growth factor (VEGF). These observations suggested that inhibitionof the Notch signaling pathway by DAPT would be useful for devising novel preventiveand therapeutic strategies targeting invasion of HCC.

oncology reports

Downregulation of the Notch signaling pathway inhibits hepatocellular carcinoma cell invasion by inactivation of matrix metalloproteinase-2 and -9 and vascular endothelial growth factor