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The sirtuin 2 (SIRT2) protein is a member of the sirtuin family and homologousto Sir2 (silent information regulator 2) of Saccharomyces cerevisiae. To assessthe pathobiological significance of SIRT2 protein expression and/or subcellularlocalization in human glioma, we examined SIRT2 protein expression in human gliomasusing a polyclonal anti-SIRT2 antibody and immunohistochemistry. In this study,samples from 23 patients with glioblastoma (GB, grade IV), 8 patients with diffuseastrocytoma (DA, grade II) and 5 healthy individuals were examined. We establisheda SIRT2 labeling index (SIRT2-LI) that represents the percentage of cells withSIRT2 localized to the nucleus. The mean SIRT2-LI was 65.8±18.6 in GB samples,41.2±22.8 in DA samples, and 28.6±12.3 in normal control samples. The SIRT2-LIof GB samples was significantly higher than that of normal control samples (P&lt;0.01,Mann-Whitney's U-test) and that of DA samples (P&lt;0.05). Moreover, the SIRT2-LIwas positively correlated with malignant progression. Specifically, samples frompatients with GB were divided into two groups, low SIRT2-LI (&lt;60%) and highSIRT2-LI (≥60%), and the patients with low SIRT2-LI samples survived significantlylonger than patients with high SIRT2-LI samples (P&lt;0.05, Kaplan-Meier methodand log-rank test). In conclusion, SIRT2-LI was indicative of glioma malignancy,and it may be predictive of GB patient survival.

Prognostic significance of sirtuin 2 protein nuclear localization in glioma: An immunohistochemical study