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Mitogen-activated protein kinase phosphatase 5 (MKP-5)/DUSP10 acts as aphosphatase of stress-activated kinases (JNK and p38), but its activity towardsERK has not been demonstrated. In the present study we observed that MKP-5 interactswith ERK, retains it in the cytoplasm, suppresses its activation and downregulatesERK-dependent transcription. These data suggested a novel MKP-5 function as ascaffold protein for the ERK pathway. We analyzed MKP-5 gene expression in severaltumors, and found that it is frequently upregulated in colorectal but not in lungand breast cancer, suggesting its association with the malignant phenotype ofcolon cancer.

Department of ENT, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China