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Although the highly proliferative, migratory and multidrug resistant phenotypeof human type II endometrial carcinoma (EC) is well characterized, improved clinicaltreatments have not yet been developed. In this study, CD44 and CD133 were usedas markers to screen, isolate and enrich carcinoma-initiating cells (CICs) fromthe human type II EC cell lines KLE and ANCA3. Using flow cytometry, we identifieda subpopulation of KLE and ANCA3 cells which express high levels of both CD44and CD133 on the cell membrane. CD44+/CD133+ EC-CICs exhibited high levels ofstemness marker genes, and possessed a higher migratory and invasive ability thanCD44-/CD133- endometrial carcinoma cells (EC-CCs). CD44+/CD133+ EC-CICs were alsomore resistant to growth inhibition induced by the chemotherapeutic drugs cisplatinand paclitaxel. Additionally, CD44+/CD133+ EC-CICs readily established tumorsin vivo in a relatively short time. In conclusion, CD44+/CD133+ cells possessingthe characteristics of CICs can be reliably sorted from KLE and ANCA3 human type IIEC cell lines, and represent a valuable model for studying cancer cell physiologyand multidrug resistance. Further characterization of CD44+/CD133+ KLE and ANCA3cells may have a profound impact on the selection of individual treatment strategies,clinical outcomes and design of the next generation of chemotherapeutic agentsfor type II EC.

oncology reports

Isolation and characterization of proliferative, migratory and multidrug-resistant endometrial carcinoma-initiating cells from human type II endometrial carcinoma cell lines