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Galectin-3-binding protein (G3BP) is highly expressed in various types ofcancer and is thought to be involved in cancer malignancy; however, the role ofG3BP in breast cancer cells is not fully understood. In this study, we investigatedthe role of NF-κB in the adhesion of breast cancer cells to a substrate by using(-)-DHMEQ, a specific inhibitor of NF-κB. (-)-DHMEQ inhibited both TNF-α-inducedG3BP expression and cell adhesion in human breast cancer cell lines. We also foundthat knockdown of G3BP suppressed the adhesion, while its overexpression increasedthe adhesion. These data reveal that (-)-DHMEQ suppresses breast cancer cell adhesionby inhibiting NF-κB-regulated G3BP expression.

Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion