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Helicobacter pylori (HP) infection is widely recognized as a risk factorfor gastric cancer, but only a minority of infected individuals develop gastriccancer. The aim of this study was to determine whether DNA demethylation in non-cancerousgastric mucosa (NGM) significantly enhances susceptibility to gastric cancer.A total of 165 healthy volunteers, including 83 HP-positive and 82-negative individuals,as well as 83 patients with single and 18 with synchronous double gastric cancer(GC) were enrolled in this study. The relative demethylation levels (RDLs) ofrepetitive sequences, including Alu, LINE-1 and Sat α, were quantified by real-timemethylation-specific polymerase chain reaction. The Alu RDL did not exhibit anydifferences within each respective group, whereas LINE-1 RDL was significantlyelevated in cancer tissues compared with the NGM in the other groups (P&lt;0.001).Our results indicated that a gradual increase in Sat α RDL correlated with HPinfection and cancer development. Sat α RDL was significantly elevated in theNGM in HP-positive compared with HP-negative (P&lt;0.001), and significantly elevatedin cancer tissues (P&lt;0.001). Although the Sat α RDL of the NGM in the totalpopulation increased in an age-dependent manner, it was significantly increasedin a fraction of younger GC patients (&lt;45 years) compared with all of the others(45 years or older, P=0.0391). In addition, double GC exhibited a significantlyhigher Sat α RDL in the NGM compared with single GC (P=0.0014). In these two fractions,Sat α RDL in the NGM exhibited an inverse correlation with age. In conclusion,the present study demonstrated that the accumulation of DNA demethylation in Satα RDL in the NGM with HP infection potentially renders susceptibility to gastriccancer in a fraction of GC patients younger than 45 years or in patients withmultiple cancers.

oncology reports

The accumulation of DNA demethylation in Sat α in normal gastric tissues with Helicobacter pylori infection renders susceptibility to gastric cancer in some individuals