English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Nestin has been detected in various malignancies and its expression correlateswith advanced grade in some neoplasms. The aim of this study was to examine nestinexpression in high-grade osteosarcomas and to determine its prognostic value.Using immunohistochemistry and immunofluorescence, we evaluated nestin expressionin tumor tissue samples from 45 patients with high-grade osteosarcomas. In bothmethods, the frequency of nestin-positive tumor cells was classified into threecategories (1+, 2+ and 3+ for immunohistochemistry; 1F+, 2F+ and 3F+ for immunofluorescence)and clinicopathological correlations were statistically evaluated and analyzed.Nestin-positive tumor cells were detected in all of the examined osteosarcomasusing both immunohistochemistry and immunofluorescence, although the proportionof undoubtedly positive neoplastic cells varied in individual samples from a fewnestin-positive tumor cells to diffuse nestin positivity. High levels of nestinexpression detected by immunofluorescence (2F+ and 3F+) were associated with worseclinical outcomes (OS, p=0.031; EFS, p&lt;0.001). However, high levels of nestinexpression as measured by immunohistochemistry trended towards shorter patientsurvival rates but did not reach statistical significance. Despite significantlyshorter survival rates observed in patients with high levels of nestin expressionassessed by immunofluorescence, nestin does not seem to represent a powerful prognosticmarker that would be superior to conventional methods.

Nestin expression in high-grade osteosarcomas and its clinical significance