English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Magnetic stent hyperthermia (MSH) is a novel approach for targeted thermotherapyfor esophageal cancer, which is based on the mechanism that inductive heat canbe generated by the esophageal stent upon exposure under an alternative magneticfield (AMF). A positive effect of MSH on esophageal cancer has been demonstrated,however, there is no study on the in vitro effects of heating treatment or ofthe effects of AMF exposure on human esophageal cancer cells. This study aimedto investigate the effect of MSH and of AMF exposure in esophageal cancer cells.Inductive heating characteristics of esophageal stents were assessed by exposingthe stents under AMF. A rather rapid temperature rise of the Ni-Ti stent whensubjected to AMF exposure was observed and the desired hyperthermic temperaturecould be controlled by adjusting the field parameter of the AMF. Human esophagealsquamous carcinoma (ESCC) ECA-109 cells were divided into four groups: the controlgroup, the water-bath heating group, the MSH group and the AMF exposure group.Hyperthermic temperatures were 43, 48 and 53˚C and the treatment time was in therange of 5-30 min. The MTT assay, apoptotic analysis and TUNEL staining were appliedin the current investigation. Exposure of ECA-109 cells under AMF with a fieldintensity of 50 to 110 kA/m had negligible effect on cell viability, cell necrosisand apoptosis. Hyperthermia had a remarkable inhibitory effect on the cell viabilityand the effect was dependent on the thermal dose (temperature and time). The optimalthermal dose of MSH for ECA-109 cells was 48˚C for 20-30 min. The study also elucidatedthat there was a difference in the effects on cell necrosis and apoptosis betweenthe heating mode of water bath and MSH. The data suggest that MSH may have clinicalsignificance for esophageal cancer treatment.

Magnetic stent hyperthermia for esophageal cancer: An in vitro investigation in the ECA-109 cell line