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The aim of this study was to investigate the effect of an adenosine A2Areceptor antagonist on the expression of glutamine synthetase (GS) and glutamateaspartate transporter (GLAST) in rat retinal Müller cells at elevated hydrostaticpressure in vitro. Immunofluorescence staining of GS and GFAP was used for theidentification of Müller cells. The expression of GS and GLAST in different hydrostaticpressure (0, 20, 40, 60, 80 mmHg/24 h) was examined by real-time PCR and Westernblotting to identify the most suitable pressure. Müller cells treated with 0.1,1, 10 µM SCH 442416 (A2A receptor antagonist) in the most suitable pressure, andthe levels of GS and GLAST were examined by real-time PCR and Western blotting.Significantly increased expression of GS and GLAST at 40 mmHg pressure was observedin Müller cells and treatment with 10 µM SCH 442416 in 40 mmHg pressure furtherpromoted the expression of GS and GLAST. A2A receptor antagonist increased theexpression of GLAST and GS of Müller cells and accelerated the clearance of extracellularglutamate.

oncology reports

In vitro effect of adenosine A2A receptor antagonist SCH 442416 on the expression of glutamine synthetase and glutamate aspartate transporter in rat retinal Mï¿½ller cells at elevated hydrostatic pressure