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MicroRNAs (miRNAs) have been implicated in regulating diverse cellular pathways.Although there is emerging evidence that various miRNAs function as oncogenesor tumor suppressors in colorectal cancer (CRC), the role of miRNAs in mediatingliver metastasis remains unexplored. The expression profile of miRNAs in livermetastasis and primary CRC tissues was analyzed by miRNA microarrays and verifiedby real-time polymerase chain reaction (PCR). In 62 CRC patients, the expressionlevels of miR-320a were determined by real-time PCR, and the effects on migrationand invasion of miR-320a were determined using a transwell assay. miR-320a targetgenes were confirmed by luciferase assay, real-time PCR and western blot analysis.A set of miRNAs was found to be dysregulated in the liver metastasis tissues comparedto matched primary CRC tissues, and the expression levels of miR-320a were significantlydecreased in the liver metastasis tissues examined. miR-320a was correlated withtumor progression in CRC. miR-320a was downregulated in liver metastatic coloncancer cells and inhibited liver metastatic colon cancer cell migration and invasion.miR-320a directly binds to the 3'UTR of neuropilin 1 (NRP-1), a protein that functionsas a co-receptor of vascular epithelial growth factor. miR-320a downregulatedthe expression of NRP-1 at both the mRNA and protein levels. These data demonstratedthat miR-320a may be useful for identifying CRC patients that are at an elevatedrisk for developing liver metastasis. Our findings suggest that miR-320a may bea novel therapeutic candidate for the treatment of colorectal cancer.

microRNA-320a inhibits tumor invasion by targeting neuropilinï¿½1 and is associated with liver metastasis in colorectal cancer