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Flavonoids are naturally occurring antioxidants, with several flavonoidsshown to have chemopreventive effects on cancer. We investigated the effects ofthe flavonoid acacetin on human T cell leukemia Jurkat cells. Acacetin inhibitedthe proliferation of Jurkat cells by inducing apoptosis in a concentration- andtime-dependent manner. Acacetin-induced cell death was characterized by changesin nuclear and cell morphology. Treatment of Jurkat cells with acacetin also inducedcaspase-3, -8 and -9 activities in a time-dependent manner. Acacetin-induced apoptosiswas blocked by a broad-spectrum caspase inhibitor, a caspase-3 inhibitor and acaspase-8 inhibitor, but not by a caspase-9 inhibitor. In addition, acacetin promotedthe expression of FAF1, phosphor-FADD, Apaf-1 and cytochrome c. Acacetin-inducedapoptosis was also accompanied by upregulation of Bax, and downregulation of Bcl-2.Taken together, these results suggest that acacetin may induce apoptosis in Tcell leukemia cells, possibly by activating the Fas-mediated pathway. These findingsmay help in designing cancer therapeutic and chemopreventive agents.

Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade