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Apart from SERPINB2 and SERPINB5, the roles of the remaining 13 membersof the human SERPINB family in cancer metastasis are still unknown. In the presentstudy, we demonstrated that most of these genes are differentially expressed intumor tissues compared to matched normal tissues from lung or breast cancer patients.Overexpression of each SERPINB gene effectively suppressed the invasiveness andmotility of malignant cancer cells. Among all of the genes, the SERPINB1, SERPINB5and SERPINB7 genes were more potent, and the inhibitory effect was further enhancedby co-expression of any two of them. In addition, single treatment of the syntheticpeptides corresponding to the P5-P5' sequences of the reactive center loop (RCL)of SERPINB1, SERPINB5 or SERPINB7 markedly suppressed the invasive and migratoryproperties of the cancer cells in a dose-dependent manner. More significantly,combination treatment of these peptides in cancer cells further improved the suppressiveeffect by 20-40%. Here, we determined the expression of all SERPINB family membersin lung and breast cancer patients, and identified those members with potent inhibitoryability toward invasion and migration, and designed RCL-derived peptides to suppressthe malignancy of cancer cells. Forced re-expression of these anti-invasive SERPINBgenes or application of the SERPINB RCL-peptides may provide a reasonable strategyagainst lethal cancer metastasis.

Suppression of the invasion and migration of cancer cells by SERPINB family genes and their derived peptides