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Pancreatic cancer (PC) is one of the most deadly malignant tumors. The aimof this study was to identify potential biomarkers for PC. Using two-dimensionalgel electrophoresis and liquid chromatography-tandem mass spectrometry, the proteomicprofiles of pancreatic cancerous and non-cancerous tissues from ten patients withPC were compared. One of the numerous spots that showed stronger intensity incancerous compared to non-cancerous tissues was identified as non-muscle cofilin(cofilin-1). This up-regulation was validated by Western blot analysis. It isnoteworthy that Western blot analysis showed significantly lower expression ofmuscle cofilin (cofilin-2) in pancreatic cancerous tissues compared to non-canceroustissues. This is the first time that cofilin isoforms (cofilin-1/2) have beenidentified to be differentially expressed in pancreatic cancerous tissues. Therefore,cofilin isoforms may serve as candidates for clinically useful biomarkers or therapeutictargets for PC.

Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues