English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The 5-year survival rate of nasopharyngeal carcinoma (NPC) is still disappointingdespite the much improved technologies in its treatment. Tumor necrosis factor-relatedapoptosis inducing ligand (TRAIL) can selectively induce apoptosis in most tumorcells while sparing normal cells. However, its potential in the treatment of NPChas been limited by the eventual emergence of drug resistance. Latent membraneprotein 1 (LMP1) is a major oncogene of the human DNA tumor virus Epstein-Barrvirus (EBV) and is associated with the development of NPC and the emergence ofchemo-resistance in NPC. In this study, we investigated the potential role ofLMP1 in TRAIL resistance in CNE-1 NPC cells. Results show that overexpressionof LMP1 could induce TRAIL resistance in NPC cells without influencing death receptors.The LMP1-induced TRAIL resistance is associated with increased expression of FLIPand elevated cleavage of caspase-8 without altering the TRAIL-mediated mitochondrialevents and Bid cleavage. Knockdown of the FLIP gene with siRNA prevented the LMP1-inducedTRAIL resistance. Furthermore, we found that overexpression of LMP1 activatedAkt. Inhibition of Akt with LY294002 completely prevented the LMP1-induced FLIPexpression and TRAIL resistance. Together, these results show that LMP1 can inhibitthe TRAIL-mediated apoptosis through activation of PI3K/Akt and expression ofFLIP in CNE-1 NPC cells, and may provide new methods to prevent and reverse drugresistance in NPC.

oncology reports

Latent membrane protein 1 mediates the resistance of nasopharyngeal carcinoma cells to TRAIL-induced apoptosis by activation of the PI3K/Akt signaling pathway