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The aim of the present study was to explore the survival of pig-rhesus cornealxenografts following donor bone marrow transplantation (BMT). Wuzhishan pigs wereused as donors and rhesus monkeys as recipients for corneal xenotransplantation.Twelve rhesus monkeys were divided into two groups. Group 1 received intravenousinjection of cyclophosphamide (CP) followed by pig bone marrow cell transplantation,while group 2 was used as a control and only received intravenous CP injection.All xenografts were evaluated using a slit-lamp microscope. The immunologicalstatus of the recipients following transplantation, including the formation ofchimerism, mixed lymphocyte reaction (MLR) and immunoglobulin and complement inthe serum, was analyzed. Two rhesus monkeys in each group were sacrificed forcorneal histopathology examination. The mean survival time was 36.0±4.7 days ingroup 1 and 17.7±3.2 days in group 2. The mean chimerism percentage in group 1at week 1 was 5.20±1.02%, but decreased with time and was &lt;1% after week 3.MLR demonstrated that immune reactivity to donor spleen cells in group 1 was decreasedfollowing surgery. Immunoglobulin and complement levels in the serum revealeda decreasing trend. Histopathological examination demonstrated that the cornealxenografts in group 1 had minimal inflammatory cell infiltration and no eosinophilinfiltration. Survival of corneal xenografts may be prolonged by prior BMT, suggestingthat immune reactivity to donors is suppressed, and is highly dependent on chimerismformation.

Survival of pig-to-rhesus corneal xenografts prolonged by prior donor bone marrow transplantation