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Recent studies have shown that microRNA-146a (miR-146a) is associated withcancer metastasis. However, the mechanisms underlying this process remain poorlyunderstood. In this study, we aimed to investigate the potential role of miR-146ain gastric cancer metastasis. A wound-healing assay and a Transwell assay wereused to investigate the impact of miR-146a on the migratory and invasive abilitiesof MKN-45 cells in vitro. MKN-45 cells stably expressing miR-146a or the negativecontrol were transplanted into nude mice through the lateral tail vein to explorethe effect of miR-146a on tumor metastasis in vivo. A luciferase reporter assayand western blot analysis were used to identify the potential target genes. Ourresults show that the overexpression of miR-146a inhibits the invasion and metastasisof MKN-45 cells in vitro and in vivo. Furthermore, the L1 cell adhesion molecule(L1CAM) was identified as a novel target of miR‑146a in gastric cancer. Takentogether, our results provide evidence that miR-146a suppresses gastric cancercell invasion and metastasis in vitro and in vivo, which may be in part due tothe downregulation of L1CAM. miR-146a may have the therapeutic potential to suppressgastric cancer metastasis.

microRNA-146a targets the L1 cell adhesion molecule and suppresses the metastatic potential of gastric cancer