English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The inhibitors of axonal regeneration in the myelin sheath are consideredto be major contributors to the lack of regeneration in the central nervous system(CNS) following hypoxic-ischemic (HI) brain damage. As well as the Nogo receptor(NgR), the paired-immunoglobulin-like receptor B (PirB) is a functional receptorfor the myelin inhibitors of axonal regeneration. The inhibition of PirB and NgRactivities may block most of the inhibitory effects of myelin inhibitors on nerveregeneration. We observed the PirB protein and mRNA expression in HI-damaged ratcortical neurons using immunohistochemistry and reverse transcription-polymerasechain reaction assays. In addition, we treated the HI-damaged rat cortical neuronsusing PirB antibodies to observe the regeneration of injured neurons. Moreover,the Rock II activity in HI-damaged rat cortical neurons treated with PirB antibodieswas observed using western blot analysis. The mRNA and protein levels of PirBincreased in newborn rat cortical neurons following HI damage. Treatment withPirB antibodies is able to improve axonal regeneration following HI damage comparedwith normal axonal growth. Rock II activity also increased in the HI-damaged ratbrain. The inhibition of PirB is therefore a potential therapeutic method to promotethe regeneration of HI-damaged axons and the inhibitory signal may be transducedthrough the Rho-ROCK signaling pathway.

PirB restricts neuronal regeneration in developing rat brain following hypoxia-ischemia