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Endoplasmic reticulum (ER) stress plays a key role in the development ofneurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF)is a natural drug derived from isothiocyanate found in cruciferous vegetables.Although there are reports indicating that SF is a potential candidate for PDtreatment, there have been no reports on the effects of SF on ER stress in PD.In this study, we investigated the cytoprotective effects of SF on 6-hydroxydopamine(6-OHDA)-induced ER stress in rat PC12 cells. Pre-treatment with SF elicited cytoprotectionagainst 6-OHDA-induced cytotoxicity. Consistent with its cytoprotective action,SF significantly inhibited subsequent ER stress, including the expression of Bipand the C/EBP homologous protein. We also found that transfection with NF-E2-relatedfactor-2 (Nrf2) siRNA reversed the inhibitory effects of SF on 6-OHDA-inducedER stress responses. In conclusion, our results show that SF can prevent ER stressresponse induced by 6-OHDA through the activation of Nrf2. SF may be a therapeuticcandidate for the treatment of ER stress-associated neural diseases, includingPD.

Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation