English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Choline kinase α (CHKA) has been identified to be associated with cancerdevelopment and progression. In this study, we investigated whether exonic singlenucleotide polymorphisms (SNPs) of the CHKA gene are associated with hepatocellularcarcinoma (HCC). Among all SNPs in the 3'-untranslated region (UTR), 5'-UTR andthe coding region of CHA, only two SNPs (rs3794186 and rs11481) in the 3'-UTRhad a heterozygosity above 0.1 and a minor allele frequency above 0.1. Therefore,we selected and assessed these two SNPs (rs3794186 and rs11481) in 189 HCC patientsand 194 controls. Genetic data were analyzed using the SNPAnalyzer Pro, SNPStatsand Haploview programs. No SNPs of the CHKA gene were found to be associated withthe risk of HCC development. Upon analysis of the clinical characteristics ofHCC, the genotypic frequency of rs3794186 was significantly associated with serumα-fetoprotein (AFP) levels (P=0.022 in the co-dominant 1 model, P=0.0045 in thedominant model and P=0.0052 in the log-additive model). A significant differencein the allelic frequency of rs3794186 was also observed between the high AFP (&gt;200 ng/ml)group and the low AFP (≤200 ng/ml) group [P=0.009, odds ratio (OR) = 0.33, 95%confidence interval (95% CI) = 0.14-0.75]. The T allele frequency of rs3794186was lower in the high AFP group (6.6%) compared to that in the low AFP group (17.8%).Our results suggest that CHKA SNPs (rs3794186 and rs11481) are not associatedwith HCC development; however, rs3794186 may correlate with serum AFP levels inHCC.

Association of CHKA polymorphism (rs3794186) with α-fetoprotein levels in hepatocellular carcinoma