English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Glucose-regulated protein 75 (Grp75), also known as mortalin/mthsp70/PBP74,is a member of the heat-shock protein 70 (HSP70) family. Grp75 is known to protectcells from stress-induced injury. Previous studies have shown that the expressionof Grp75 is upregulated by a low dose of ionizing radiation (IR). To evaluatethe protective role of Grp75 on cell proliferation in response to IR, Grp75 wasoverexpressed in a rat adrenal pheochromocytoma cell line (PC12). It was revealedthat Grp75 overexpression desensitized PC12 cells to IR-mediated cell injury.In addition, the expression of topoisomerase IIα (Topo IIα) was downregulatedin PC12 cells following γ-ray IR. The effect of Grp75 overexpression on Topo IIαexpression was examined. It was revealed that Grp75 overexpression reversed theinhibitory effect of IR on Topo IIα expression. In conclusion, the data indicatedthat Grp75 overexpression attenuates IR-induced injury in PC12 cells by maintainingthe expression of Topo IIα.

molecular medicine reports

Glucose-regulated protein 75 overexpression attenuates ionizing radiation-mediated injury in PC12 cells by inducing the expression of topoisomerase IIα