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Previous research has shown that the Dwarf lilyturf tuber has antitumoreffects. The antitumor ability of DT-13, a saponin monomer isolated from the rootsof the Dwarf lilyturf tuber, is discussed in this study. The results showed thatDT-13 inhibited the proliferation, adhesion and invasion of MDA-MB-435 cells.DT-13 decreased the excretion and expression of MMP-2/9. Furthermore, DT-13 inhibitedthe phosphorylation of p38 in MDA-MB-435 cells. In conclusion, the results suggestthat DT-13 possesses anticancer and antimetastatic properties by inhibiting theinvasion of cancer cells.

DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway