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The aim of this study was to investigate the relationship between E-selectin+G98T, +A561C polymorphisms and the levels of hepatitis B virus (HBV) DNA andpreS1 antigen (preS1Ag) in patients with chronic hepatitis B (CHB) infection.Polymorphisms of the E-selectin gene in 150 CHB patients and 150 healthy controlsof two different nationalities were detected using polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP). Real-time quantitative PCR was used todetect the levels of HBV DNA. preS1Ag and five items of hepatitis B were detectedby enzyme-linked immunosorbent assay. Two genotypes, GG (94%, 96%) and GT (6%,4%) of the E-selectin +G98T polymorphism, and AA (78.67%, 80.67%) and AC (21.33%,19.33%) of the +A561C polymorphism, were found in these patients. There were alsosignificant differences in the two nationalities in the genotypic frequenciesin +A561C polymorphisms between patients and healthy subjects (χ2=5.489, χ2=5.653;P&lt;0.05). In the patients studied, the relative risk of suffering from CHB ingenotype AC was 2.122 and 2.313-fold higher for the two nationalities, respectively,than that of the AA genotype (OR=2.122, 95% CI 1.121-4.019; OR=2.313, 95% CI 1.002-5.360).There was also significant over-representation in the C allele frequency betweenthe two groups (χ2=5.000, χ2=5.30; P&lt;0.05), and the levels of HBV DNA and preS1Agin the AC genotype patients were higher than those in the AA genotype (P&lt;0.01and P&lt;0.05). E-selectin +A561C and +G98T polymorphisms were present in thepopulations studied. Therefore, there is a correlation between E-selectin +A561Cpolymorphisms and CHB. Allele C may be one of the predisposing factors, and mutationof this locus may impact the virus copy number.

molecular medicine reports

Association between polymorphisms of the E-selectin gene, hepatitis B virus DNA copies and preS1 antigen in patients with chronic hepatitis B infection