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The herb Liriope platyphylla (LP) has been considered to have curative propertiesfor diabetes, asthma and neurodegenerative disorders. To examine the effects ofsteaming time and frequency of manufactured red LP (RLP) on the nerve growth factor(NGF) secretion ability and NGF receptor signaling pathway, the NGF concentration,cell differentiation, NGF signaling pathway and calcium concentration were analyzedin neuronal cells treated with several types of LPs manufactured under differentconditions. The maximum NGF secretion was observed in B35 cells treated with 50µg/ml LP extract steamed for 9 h (9-SLP) and with two repeated steps (3 h steamingand 24 h air-dried) carried out 7 times (7-SALP). No significant changes in viabilitywere detected in any of the cells treated with the various LPs, with the exceptionof 0-SLP and 0-SALP. In addition, PC12 cell differentiation was induced by treatmentwith the NGF-containing conditional medium (CM) collected from the RLP-treatedcells. The levels of TrkA and extracellular signal-regulated kinase (ERK) phosphorylationin the high affinity NGF receptor signaling pathway were significantly higherin the cells treated with 3-SLP or 1-SALP/3-SALP CM compared with those treatedwith the vehicle CM. In the low affinity NGF receptor pathway, the expressionlevels of most components were higher in the 9-, 15- and 24-SALP CM-treated cellscompared with the vehicle CM-treated cells. However, this level was significantlyaltered in cells treated with 3-SALP CM. Furthermore, an examination of the RLPfunction on calcium regulation revealed that only the LP- or RLP-treated cellsexhibited changes in intracellular and extracellular calcium levels. RLP induceda significant decrease in the intracellular calcium levels and an increase inthe extracellular calcium levels. These results suggest the possibility that steaming-processedLP may aid in the relief of neurodegenerative diseases through the NGF secretionability and NGF signaling pathway.

molecular medicine reports

Differential effects of the steaming time and frequency for manufactured red Liriope platyphylla on nerve growth factor secretion ability, nerve growth factor receptor signaling pathway and regulation of calcium concentration