English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Perineural invasion (PNI) is common in salivary adenoid cystic carcinoma(SACC). The aim of the present study was to explore the association of the Schwann-likecell differentiation with PNI in SACC. Twenty-eight cases of SACC and 10 casesof acinic cell carcinoma (ACA) were examined for the expression of the Schwanncell markers Leu-7 by immunohistochemical staining. The correlation between Leu-7expression and PNI was analyzed using κ analysis. Immunofluorescence double-stainingand pre-embedding immunogold-silver cytochemistry were used to detect the co-expressionand the location of Leu-7 and the myoepithelial cell marker α-smooth muscle actin(α-SMA). PNI was identified in 16 SACCs (57.1%) and 1 ACA (10%) and the overexpressionof Leu-7 was detected in 22 SACCs (78.6%) and in none of the ACAs (0%). The differencesbetween PNI and Leu-7 expression in SACC and ACA were significant (P&lt;0.05).A correlation was identified between the expression of Leu-7 and PNI in SACC (κ=0.533,P=0.01). In SACC, Leu-7 and α-SMA were co-expressed in the cytoplasm in the samemyoepithelial cells. We suggest that Schwann‑like cell differentiation correlateswith PNI in SACC and that the differentiation of myoepithelial into Schwann‑likecells may be one of the mechanisms through which PNI occurs in SACC.

Investigation of myoepithelial cell differentiation into Schwann-like cells in salivary adenoid cystic carcinoma associated with perineural invasion