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This study aimed to investigate the involvement of c-erbB-2, encoded bythe receptor tyrosine kinase ERBB2 gene, in the pathogenesis of colorectal cancerand to validate its potential as an anticancer target. Immunohistochemical andhistopathological analyses were applied in tissue samples derived from 80 colorectalcancer patients. ERBB2 stable small hairpin RNA (shRNA) knockdown in HT29 humancolorectal cancer cells was confirmed by RT-PCR and western blotting. Cell cycleprofile and apoptosis were measured using PI or Annexin V-PI dual staining. Asignificant correlation between ERBB2 levels and Dukes' stage of colorectal cancer,in both the primary malignancy and lymph node metastatic tissues, was observed.ERBB2-depleted HT-29 cells exhibited increased sensitivity to radiation comparedto control cells, likely due to enhanced G0/G1 phase cell cycle arrest and apoptosis.ERBB2 may be involved in the malignancy and metastasis of colorectal cancer. OverexpressedERBB2 may constitute a potential target for colorectal cancer therapy.

RNAi-mediated ERBB2 gene knockdown sensitizes human colorectal cancer cells to radiation