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The aim of the present study was to investigate the apoptosis of human ovariancancer cell lines, A2780 and CP70, induced by a novel curcumin analogue, B19.The proliferation of cells was detected with methyl thiazolyl tetrazolium (MTT)assay and apoptosis was examined by flow cytometry. Reactive oxygen species (ROS)were assessed by the fluorescent indicator DCF-DA. The protein expression of theendoplasmic reticulum (ER) stress pathways, GRP78, XBP-1, ATF-4 and CHOP, wasexamined with Western blotting. A growth inhibitory effect was observed aftertreatment with B19 in a dose-dependent manner and with more potential than curcumin.At 20 µM, B19 induced significant apoptosis in CP70 cells. Furthermore, B19 inducedthe ER stress response, while curcumin had no effect on ER stress. These resultssuggest that B19 has more effective antitumor properties than curcumin, and isassociated with the activation of ER stress and ROS in ovarian cancer cells.

molecular medicine reports

A novel mono-carbonyl analogue of curcumin induces apoptosis in ovarian carcinoma cells via endoplasmic reticulum stress and reactive oxygen species production