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The objective of the present study was to investigate the expression ofpaxillin and focal adhesion kinase (FAK) mRNA in esophageal carcinoma tissues,and their relationship with clinicopathological parameters, as well as to analyzethe correlation of paxillin and FAK mRNA levels in esophageal carcinoma. By usingreverse transcription polymerase chain reaction (RT-PCR), the mRNA expressionlevels of paxillin and FAK were detected in 121 samples of esophageal carcinoma,43 samples of atypical hyperplasia and 56 samples of normal esophageal mucosa.The results showed that the positive rates of paxillin and FAK mRNA expressionin esophageal carcinoma were 87.6 and 80.17%, respectively, which were significantlyhigher (P&lt;0.05) than those in atypical hyperplasia (44.19 and 39.53%) and normalesophageal mucosa (5.36 and 12.5%). Notably, paxillin and FAK mRNA expressionlevels were significantly correlated with the differentiation degree and depthof invasion of esophageal carcinoma and with lymph node metastasis (P&lt;0.05).In addition, paxillin and FAK mRNA expression levels in esophageal carcinoma werepositively correlated (r=0.4804, P=0.000). In conclusion, the combined detectionof paxillin and FAK mRNA expression is expected to provide a theoretical basisfor the molecular diagnosis of esophageal carcinoma.

Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma